Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression (NCT05966532)
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression (ENSURE; R21 MH130870)
🩺 Plain-English Summary (8th-Grade Level)
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.
Who can join: Review the eligibility criteria below.
Location: University of Texas Arlington — Arlington, Texas
Age range: 21 Years to 80 Years
🧪 Interventions in This Study
- Hot Cognitive Task (BEHAVIORAL)
- Cold cognitive tasks (BEHAVIORAL)
- Structural magnetic resonance imaging (sMRI) (OTHER)
- Magnetoencephalography imaging (MEG) (OTHER)
- four self-report forms per the requirement of the NIH Common Data Elements project (BEHAVIORAL)
- Four self-report measures to assess interpersonal functioning (BEHAVIORAL)
- Clinical assessments (BEHAVIORAL)
- ATHF (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- University of Texas Arlington — Arlington, Texas
- University of Texas Southwestern Medical Center — Dallas, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.