41 Recruiting Major Depressive Disorder (MDD) Clinical Trials
Explore open interventional and observational research studies actively enrolling participants across the USA. Verify eligibility and contact site coordinators directly.
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Top Interventions for Major Depressive Disorder (MDD)
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Top Recruiting Major Depressive Disorder (MDD) Studies
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
📍 University of Texas Arlington — Arlington, Texas
View Study & Checklist ➔Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)
📍 Baycrest Hospital — Toronto, Ontario
View Study & Checklist ➔Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
📍 New York State Psychiatric Institute — New York, New York
View Study & Checklist ➔Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
📍 Sunnybrook Health Sciences Centre — Toronto, Ontario
View Study & Checklist ➔REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness
📍 Yale Greenwich Hospital Interventional Psychiatry Services — Greenwich, Connecticut
View Study & Checklist ➔Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
📍 Centre for Addiction and Mental Health — Toronto, Ontario
View Study & Checklist ➔Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
📍 Collaborative Neuroscience Network — Garden Grove, California
View Study & Checklist ➔A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
📍 UAB Psychiatry and Behavioral Neurology — Birmingham, Alabama
View Study & Checklist ➔Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
📍 Vanda Investigational Site — Phoenix, Arizona
View Study & Checklist ➔Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
📍 St. Michael's Hospital, Unity Health Toronto — Toronto, Ontario
View Study & Checklist ➔Home-Based tDCS for Depression in BPD
📍 IUSMM — Montreal, Quebec
View Study & Checklist ➔Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
📍 Rotman Research Institute at Baycrest — Toronto, Ontario
View Study & Checklist ➔A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
📍 Seaport Investigator Site — Chino, California
View Study & Checklist ➔The Role of mGluR5 in CBT-I
📍 Stony Brook University: Dept of Psychiatry — Stony Brook, New York
View Study & Checklist ➔Neurofeedback to Treat Depression - 2
📍 Center for Neuromodulation in Depression and Stress — Philadelphia, Pennsylvania
View Study & Checklist ➔ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
📍 Brain and Cognition Discovery Foundation — Toronto, Ontario
View Study & Checklist ➔A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
📍 Draig Clinical Site — Bentonville, Arkansas
View Study & Checklist ➔Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression
📍 Royal Ottawa Mental Health Centre — Ottawa, Ontario
View Study & Checklist ➔Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
📍 UC Davis Medical Center — Sacramento, California
View Study & Checklist ➔Home-Based tDCS Treatment Of Major Depressive Disorder
📍 Curavit Clinical Research (virtual study site) — Boston, Massachusetts
View Study & Checklist ➔Evaluating Conversational Artificial Intelligence for Depression Management
📍 George Mason University — Fairfax, Virginia
View Study & Checklist ➔Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
📍 Portland VA Medical Center — Portland, Oregon
View Study & Checklist ➔Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
📍 University of Calgary — Calgary, Alberta
View Study & Checklist ➔Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
📍 Kernel — Los Angeles, California
View Study & Checklist ➔Theta-Burst Stimulation to Treat Depression
📍 Centre for Addiction and Mental Health — Toronto, Ontario
View Study & Checklist ➔Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
📍 University of Pennsylvania — Philadelphia, Pennsylvania
View Study & Checklist ➔Pattern Separation in Major Depressive Disorder
📍 New York State Psychiatric Institute (NYSPI) — New York, New York
View Study & Checklist ➔PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
📍 Stony Brook University: Dept of Psychiatry — Stony Brook, New York
View Study & Checklist ➔Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
📍 Cincinnati Childrens Hospital Medical Center — Cincinnati, Ohio
View Study & Checklist ➔A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
📍 Draig Clinical Site — Phoenix, Arizona
View Study & Checklist ➔Mechanisms Of Orbitofrontal Stimulation in Depression
📍 Beth Israel Deaconess Medical Center — Boston, Massachusetts
View Study & Checklist ➔