ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response (NCT07284667)
A Double-Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Study of ACP-211 Monotherapy in Adults With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatment resistant depression (TRD). The main questions the study aims to answer are: * Does ACP-211 work better than a placebo (a look-alike capsule with no medicine) to reduce symptoms of depression? * What adverse events do participants have when taking ACP-211?
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- Inland Psychiatric Medical Group — Chino, California
- Behavioral Research Specialists, LLC — Glendale, California
- Kadima Neuropsychiatry Institute — La Jolla, California
- PNS Clinical Research LLC dba ATP Clinical Research — Orange, California
- Mountain View Clinical Research — Denver, Colorado
- New Access Research and Medical Services, Inc. — Fort Myers, Florida
- The Medici Medical Research — Hollywood, Florida
- Sandhill Research, LLC/DBA Accel Research Sites — Largo, Florida
- Clinical Neuroscience Solutions, Inc. — Orlando, Florida
- IPTB Clinical Research — Tampa, Florida
- Neuroscience Research Institute, Inc. — West Palm Beach, Florida
- Adams Clinical, Inc. — Watertown, Massachusetts
- Vitalix Clinical, Inc. — Worcester, Massachusetts
- Precise Research Centers — Flowood, Mississippi
- St. Charles Psychiatric Associates, Inc. dba Midwest Research Group — Saint Charles, Missouri
- Alivation Research, LLC — Lincoln, Nebraska
- Redbird Research LLC — Las Vegas, Nevada
- CenExel Hassman Research Institute, LLC — Marlton, New Jersey
- Integrative Clinical Trials LLC — Brooklyn, New York
- Magnolia Clinical Research, LLC — Cary, North Carolina
- Neuro-Behavioral Clinical Research — North Canton, Ohio
- Baylor College of Medicine — Houston, Texas
- Dynamed Clinical Research LP d/b/a DM Clinical Research — Houston, Texas
- Olympus Clinical Research, LLC — Katy, Texas
📞 Contact the Study Coordinator
Phone: (609) 250-6920
Email: sfilosi@ACADIA-Pharm.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Major Depressive Disorder (MDD)
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- Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT) — Toronto, Ontario
- Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts — New York, New York
- Ketogenic Diet and Neuromodulation in Treatment Resistant Depression — Toronto, Ontario
- REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness — Greenwich, Connecticut
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Explore by condition: All Major Depressive Disorder (MDD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.