The STOP-MED CTRCD Trial (NCT06183437)
A Multi-Centre Non-Inferiority Randomized Controlled Trial of STOPping Cardiac MEDications in Patients With Normalized Cancer Therapy Related Cardiac Dysfunction: The STOP-MED CTRCD Trial
🩺 Plain-English Summary (8th-Grade Level)
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart from progressing to heart failure. With early detection and treatment, heart function recovers to normal in \>80% of patients. Unfortunately, heart failure medications are associated with an undesirable long-term pill burden, financial costs, and side-effects (e.g., dizziness and fatigue). As a result, cancer survivors frequently ask if they can safely stop their heart failure medications once their heart function has returned to normal. Currently there is no scientific evidence in this area of Cardio-Oncology. To address this knowledge gap, the investigators have designed a randomized control trial to assess the safety of stopping heart failure medication in patients with CTRCD and recovered heart function. The investigators will enrol patients who have completed their cancer therapy and are on heart medications for their CTRCD, which has now normalized. The investigators will randomize patients with no other reasons to continue heart failure medications (e.g., kidney disease) to continuing or stopping their heart medications safely. All patients will undergo a cardiac MRI at baseline, 1 and 5 years with safety assessments at 6-8 weeks, 6 months and 3 and 5 years. The investigators will determine if stopping medications is non-inferior to continuing medications by counting the numbers of patients who develop heart dysfunction by 1 year in each group.
Who can join: Review the eligibility criteria below.
Location: University of California, Los Angeles — Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
- Stopping Heart Failure Medication(s) (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- University of California, Los Angeles — Los Angeles, California
- Brigham and Women's Hospital — Boston, Massachusetts
- Baker Heart and Diabetes Institute — Melbourne, Victoria
- Cardio-Oncology Clinic, MAHI, University of Alberta Hospital — Edmonton, Alberta
- St. Boniface Hospital — Winnipeg, Manitoba
- Hamilton General Hospital — Hamilton, Ontario
- University of Ottawa Heart Institute — Ottawa, Ontario
- St Michael's Hospital — Toronto, Ontario
- University Health Network — Toronto, Ontario
- Maria Sklodowska-Curie National Research Institute of Oncology — Warsaw,
- La Paz University Hospital — Madrid,
- Barts Health NHS Trust, University College London — London, London
- Liverpool Heart and Chest Hospital — Liverpool,
- Guy's and St Thomas' NHS Foundation Trust (Royal Brompton Hospital) — London,
📞 Contact the Study Coordinator
Phone: (416) 340-5326
Email: dinesh.thavendiranathan@uhn.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure
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Explore by condition: All Heart Failure clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.