🏛️ Verified NIH Record • Updated 2026-06-03
A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam) (NCT06223360)
A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Alzheimer's Disease Cooperative Study (ADCS)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to learn more about the safety, effectiveness and tolerability of the study drug called Benfotiamine which may delay or slow the progression of the symptoms of early Alzheimer's disease.
Who can join: Review the eligibility criteria below.
Location: St. Joseph's Hospital and Medical Center/Barrow Neurological Institute — Phoenix, Arizona
Age range: 50 Years to 89 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (47 Sites)
Showing the first 25 of 47 sites.
- St. Joseph's Hospital and Medical Center/Barrow Neurological Institute — Phoenix, Arizona
- Perseverance Research Center, LLC — Scottsdale, Arizona
- Banner Sun Health Research Institute — Sun City, Arizona
- The Neuron Clinic — Chula Vista, California
- University of California, Irvine — Irvine, California
- Pacific Research Network — Lemon Grove, California
- University of Southern California — Los Angeles, California
- Cedars Sinai, Los Angeles — Los Angeles, California
- Syrentis Clinical Research — Santa Ana, California
- JEM Research Institute — Atlantis, Florida
- Brain Matters Research — Delray Beach, Florida
- Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida
- CCM Clinical Research Group, LLC — Miami, Florida
- Gonzalez MD & Aswad MD Health Services — Miami, Florida
- Miami Jewish Health — Miami, Florida
- Blue Medical Research Inc. — Miami, Florida
- Brainstorm Research — Miami, Florida
- Brain Matters Research (Kane Center) — Stuart, Florida
- Conquest Research — Winter Park, Florida
- Emory University Goizueta Alzheimer's Disease Research Center(GADRC) — Atlanta, Georgia
- Sandhill Research, LLC d/b/a Accel Research Sites — Decatur, Georgia
- Northwestern University Feinberg School of Medicine — Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois
- Southern Illinois University — Springfield, Illinois
- University of Iowa — Iowa City, Iowa
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alzheimer Disease
- The Use of Memantine for Prevention of Alzheimer's Disease — Charlottesville, Virginia
- Investigation of Inflammation Using [C-11]-CS1P1 — St Louis, Missouri
- Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia — Palo Alto, California
- A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (HOPE Study) — Gilbert, Arizona
- High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease — Cambridge, Massachusetts
- A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease — Phoenix, Arizona
Explore by condition: All Alzheimer Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.