Emergency Medicine Pulmonary Embolism Testing Multicentre Study (NCT06320236)
๐ฉบ Plain-English Summary (8th-Grade Level)
It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging. A new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results. The study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.
Who can join: Review the eligibility criteria below.
Location: Hamilton Health Sciences Corporation โ Hamilton, Ontario
Age range: 18 Years
๐งช Interventions in This Study
- Adjust-Unlikely (DIAGNOSTIC_TEST)
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (4 Sites)
- Hamilton Health Sciences Corporation โ Hamilton, Ontario
- Kingston Health Sciences Centre โ Kingston, Ontario
- London Health Sciences Centre Research Inc โ London, Ontario
- Ottawa Hospital Research Institute โ Ottawa, Ontario
๐ Contact the Study Coordinator
Phone: (416) 566-3590
Email: natasha.clayton@queensu.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Pulmonary Embolism
- Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism โ Birmingham, Alabama
- Novel ฮฑ2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial โ Phoenix, Arizona
- Comparing Electrical Impedance Tomography to Computed Tomographic Angiography โ Loveland, Colorado
- Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE โ Bay Shore, New York
- Michigan Emergency Department Improvement Collaborative (MEDIC) Alert; Pulmonary Embolism (PE) โ Ann Arbor, Michigan
- Pulmonary Embolism International THrOmbolysis Study-3 โ Linz,
Explore by condition: All Pulmonary Embolism clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.