🏛️ Verified NIH Record • Updated 2025-10-23
A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD) (NCT06335173)
A Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Intravenous Sabirnetug in Early Alzheimer's Disease
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Acumen Pharmaceuticals
🩺 Plain-English Summary (8th-Grade Level)
The primary purpose of this study is to evaluate the efficacy of sabirnetug infusions administered once every four weeks (Q4W) in slowing cognitive and functional decline as compared to placebo in participants with early Alzheimer's disease.
Who can join: Review the eligibility criteria below.
Location: The Neurology Center of Southern California - Carlsbad — Carlsbad, California
Age range: 50 Years to 90 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (68 Sites)
Showing the first 25 of 68 sites.
- The Neurology Center of Southern California - Carlsbad — Carlsbad, California
- Neurology Center of North Orange County — Fullerton, California
- Irvine Medical Research — Irvine, California
- Healthy Brain Research — Long Beach, California
- Syrentis Clinical Research — Santa Ana, California
- CenExel - California Neuroscience Research Medical Group, Inc (CNR) — Sherman Oaks, California
- Research Center for Clinical Studies, LLC — Norwalk, Connecticut
- Re:Cognition Health - Fairfax — Washington D.C., District of Columbia
- JEM Research Institute — Atlantis, Florida
- Bradenton Research Center — Bradenton, Florida
- Gil Fernandez-Yera, MD, PA — Coral Gables, Florida
- Brain Matters Research — Delray Beach, Florida
- Coral Clinical Research — Homestead, Florida
- K2 Medical Research - Villages — Lady Lake, Florida
- Finlay Medical Research — Miami, Florida
- Aqualane Clinical Research — Naples, Florida
- Ocala Health - Family Care Specialists - Ocala I — Ocala, Florida
- Progressive Medical Research — Port Orange, Florida
- Alzheimer's Research and Treatment Center - Stuart — Stuart, Florida
- K2 Medical Research - Tampa — Tampa, Florida
- Charter Research - Lady Lake — The Villages, Florida
- Alzheimers Research and Treatment Center - Wellington — Wellington, Florida
- Conquest Research — Winter Park, Florida
- Charter Research - Winter Park — Winter Park, Florida
- Columbus Memory Center — Columbus, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.