A Phase 1/2 Study of OBI-992 in Subjects With Advanced Solid Tumors (NCT06480240)
A Phase 1/2, Open-Label, Dose-Escalation and Cohort-Expansion Study Evaluating the Safety, Pharmacokinetics, and Therapeutic Activity of OBI-992 in Subjects With Advanced Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
This is a 2-part trial: Part A (Dose Escalation) is designed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of OBI-992 (Anti-TROP2 antibody drug conjugate, anti-TROP2 monoclonal antibody-cleavable peptide linker-exatecan) as monotherapy. Part B (Cohort Expansion) is intended to further characterize the safety and preliminary clinical activity profile of the RP2D of OBI-992 in subjects with advanced solid tumors.
Who can join: Review the eligibility criteria below.
Location: California Clinical Trials Medical Group (CCTMG) — Glendale, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (8 Sites)
- California Clinical Trials Medical Group (CCTMG) — Glendale, California
- Scripps Green Hospital — La Jolla, California
- Karmanos Cancer Institute — Detroit, Michigan
- The University of Texas MD Anderson Cancer Center — Houston, Texas
- NEXT Oncology — San Antonio, Texas
- NEXT Virginia — Fairfax, Virginia
- Taipei Tzu Chi Hospital — New Taipei City, Xindian District
- Taipei Medical University - Shuang Ho Hospital — New Taipei City, Zhonghe District
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Advanced Solid Tumor clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.