🏛️ Verified NIH Record • Updated 2026-08-06
SIMPLAAFY Clinical Trial (NCT06521463)
WATCHMAN FLX™ Pro Left Atrial Appendage Closure Device With Alternative Post-Implant Monotherapy
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Boston Scientific Corporation
🩺 Plain-English Summary (8th-Grade Level)
The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following post-implant with the WATCHMAN FLX Pro device in a commercial clinical setting.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (86 Sites)
Showing the first 25 of 86 sites.
- University of Alabama Birmingham — Birmingham, Alabama
- Grandview Medical Center — Birmingham, Alabama
- Phoenix Cardiovascular Research Group — Phoenix, Arizona
- HonorHealth Heart Group - Shea — Scottsdale, Arizona
- Tucson Medical Center Healthcare — Tucson, Arizona
- Arrhythmia Research Group — Jonesboro, Arkansas
- Mills Peninsula Health Services — Burlingame, California
- John Muir Medical Center — Concord, California
- Scripps Memorial Hospital — La Jolla, California
- Loma Linda University Medical Center — Loma Linda, California
- St. John's Health Center — Los Angeles, California
- Santa Barbara Cottage Hospital — Santa Barbara, California
- Los Robles Hospital & Medical Center — Thousand Oaks, California
- Cardiology Associates Medical Group — Ventura, California
- Colorado Heart and Vascular PC — Lakewood, Colorado
- Medical Center of the Rockies — Loveland, Colorado
- Hartford Hospital — Hartford, Connecticut
- Washington Hospital — Washington D.C., District of Columbia
- Baptist Medical Center — Jacksonville, Florida
- Naples Community Hospital — Naples, Florida
- Sarasota Memorial Hospital — Sarasota, Florida
- Emory University Hospital — Atlanta, Georgia
- Georgia Arrhythmia Consultants — Macon, Georgia
- Wellstar Kennestone Hospital — Marietta, Georgia
- Memorial Health University Medical Center — Savannah, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.