Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction (NCT06736574)
A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Assess Efficacy and Safety of Omecamtiv Mecarbil in Patients With Symptomatic Heart Failure With Severely Reduced Ejection Fraction (COMET-HF)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
Who can join: Review the eligibility criteria below.
Location: Advanced Cardiovascular, LLC — Alexander City, Alabama
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (205 Sites)
Showing the first 25 of 205 sites.
- Advanced Cardiovascular, LLC — Alexander City, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama
- Pima Heart and Vascular Clinical Research — Tucson, Arizona
- National Heart Institute — Beverly Hills, California
- UC San Diego Health - Sulpizio Cardiovascular Center — La Jolla, California
- Nutrition Research Center (SPH) — Loma Linda, California
- Keck Medical Center of USC (outpatient clinic) — Los Angeles, California
- UCLA Medical Center Cardiovascular Clinic — Los Angeles, California
- University of California, Irvine Medical Center — Orange, California
- Sutter Institute for Medical Research (SIMR) — Sacramento, California
- UC Davis Health — Sacramento, California
- San Diego Cardiac Center — San Diego, California
- California Pacific Medical Center Van Ness Campus — San Francisco, California
- Kaiser Permanente Santa Clara — Santa Clara, California
- Stanford University Hospital / Stanford Health Care — Stanford, California
- Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center — Torrance, California
- Rocky Mountain Regional VA Medical Center — Aurora, Colorado
- Cardiology Associates of Fairfield County, P.C — Bridgeport, Connecticut
- Hartford Hospital — Hartford, Connecticut
- Yale New Haven Health Heart & Vascular Center Outpatient Services — New Haven, Connecticut
- CHF Heart Clinical (Subject Visits & IP Shipments) — Clearwater, Florida
- Holy Cross Medical Group - Cardiology Associates — Fort Lauderdale, Florida
- South Florida Research Solutions, LLC — Hollywood, Florida
- UF Health Jacksonville — Jacksonville, Florida
- Broward Research Center — Miami Beach, Florida
📞 Contact the Study Coordinator
Phone: (650) 624-2929
Email: medicalaffairs@cytokinetics.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Failure
- REDUCE LAP-HFREF TRIAL — New York, New York
- Physiological Effects Ketone Ester in Heart — Cleveland, Ohio
- DASH Diet in Heart Failure Outpatients — Sacramento, California
- Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients — Huntsville, Alabama
- LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. — Birmingham, Alabama
- A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation — Alexander City, Alabama
Explore by condition: All Heart Failure clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.