Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock (NCT06746753)
Mechanistic Assessment of Norepinephrine TheRapy vs. Angiotensin-II in Septic Shock (MANTRA) Grant Submission- Dysfunctional Renin-Angiotensin System in Septic Shock
🩺 Plain-English Summary (8th-Grade Level)
Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exogenous Angiotensin II versus norepinephrine (conventional care) treatment in septic shock patients. This trial will determine whether there are better predictors of septic shock severity. This approach may inform more appropriate treatment regimens and improve outcomes for these patients.
Who can join: Review the eligibility criteria below.
Location: Massachusetts General Hospital-Harvard — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Massachusetts General Hospital-Harvard — Boston, Massachusetts
- Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina
📞 Contact the Study Coordinator
Phone: (513) 658-5866
Email: ashish.khanna@wfusm.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Septic Shock
- Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study — Birmingham, Alabama
- Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance — Cleveland, Ohio
- Blood Purification for the Treatment of Pathogen Associated Shock — Washington D.C., District of Columbia
- Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock — London, Ontario
- Evaluating Dynamic Arterial Elastance in Septic Shock Patients. — Bogotá,
- Randomized Control Study in REsuscitation of SEpsis Trial — Bogotá, Bogota D.C.
Explore by condition: All Septic Shock clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.