Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01) (NCT06819007)
A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01/ENGOT-ov89/GEICO144- O/GOG-3112/APGOT-OV13)
🩺 Plain-English Summary (8th-Grade Level)
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
Who can join: Review the eligibility criteria below.
Location: Disney Family Cancer Center — Burbank, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (208 Sites)
Showing the first 25 of 208 sites.
- Disney Family Cancer Center — Burbank, California
- Scripps Clinic — La Jolla, California
- Palo Alto Medical Foundation — Palo Alto, California
- Broward Health Medical Center — Fort Lauderdale, Florida
- Jupiter Medical Center — Jupiter, Florida
- Mount Sinai Medical Center — Miami Beach, Florida
- AdventHealth Cancer Institute — Orlando, Florida
- Woman's Care FL — St. Petersburg, Florida
- Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System — Savannah, Georgia
- Endeavor Health Evanston Kellogg Cancer Care Center — Evanston, Illinois
- Indiana University — Indianapolis, Indiana
- Trials365 LLC — Shreveport, Louisiana
- Greater Baltimore Medical Center — Towson, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Trinity Health St. Joseph Mercy Ann Arbor — Ann Arbor, Michigan
- Corewell Health — Grand Rapids, Michigan
- Minnesota Oncology Hematology PA — Minneapolis, Minnesota
- St. Vincent Gynecologic Oncology — Billings, Montana
- Valley Health System — Paramus, New Jersey
- Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York, New York
- Icahn School of Medicine at Mount Sinai — New York, New York
- Columbia University — New York, New York
- UNC Hospital — Chapel Hill, North Carolina
- Miami Valley Hospital South — Centerville, Ohio
📞 Contact the Study Coordinator
Phone: (908) 992-6400
Email: CTRinfo_us@daiichisankyo.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Ovarian Cancer
- Prehabilitation Care for Women With Advanced Ovarian Cancer Receiving Neoadjuvant Chemotherapy — New York, New York
- Safety and Efficacy of Anti-CD47, ALX148 in Combination With Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer — Pittsburgh, Pennsylvania
- Trial on Radical Upfront Surgery in Advanced Ovarian Cancer — New York, New York
- Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) — Duarte, California
- Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302) — Little Rock, Arkansas
- NeoVax With Nivolumab in Patients With Ovarian Cancer — Boston, Massachusetts
Explore by condition: All Ovarian Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.