Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS (NCT06854627)
Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position on Mortality in ARDS Patients: A Multicenter Randomized Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
Prone position (placing the patient on his abdomen) has been shown to be an effective intervention to decrease mortality in adults connected to mechanical ventilation for moderate to severe Acute Respiratory Distress Syndrome (ARDS). Patients may require one or more sessions of prone position. However, the optimal duration of prone sessions is unknown. The goal of this clinical trial is to learn if applying prone position in prolonged sessions (\> 48 hours - prolonged prone position) is more effective than applying it in daily sessions (16 to 24 hours - intermittent prone position). The trial will also learn about the safety of prolonged prone position compared to intermittent prone position. The main questions it aims to answer are: * Does prolonged prone position increase survival compared to intermittent prone position in participants with moderate to severe ARDS ? * How does prolonged prone position compare to intermittent prone position in terms of medical problems associated to prone position ? Researchers will compare prolonged versus intermittent prone position to see which approach is better to treat moderate to severe ARDS. Participants will: * Receive prone position either in prolonged (\> 48 hours) or daily (16 to 24 hours) sessions during the first 7 days * Be followed for up to 90 days to assess their clinical evolution
Who can join: Review the eligibility criteria below.
Location: Hospital Britanico — Buenos Aires
Age range: 18 Years
🧪 Interventions in This Study
- Daily prone position sessions (PROCEDURE)
- Prolonged prone position sessions (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (38 Sites)
Showing the first 25 of 38 sites.
- Hospital Britanico — Buenos Aires,
- Sanatorio Güemes — Buenos Aires,
- Sanatorio Mitre — Buenos Aires,
- Hospital San Martin de la Plata, Argentina — La Plata,
- Hospital Vera Barros — La Rioja,
- Hospital Privado de comunidad — Mar del Plata,
- Hospital Leonardo Guzmán — Antofagasta,
- Hospital Clínico Herminda Martín — Chillan,
- Hospital Guillermo Grant Benavente — Concepción,
- Hospital San Juan de Dios de Curicó — Curicó,
- Hospital Regional Dr. Ernesto Torres Galdames — Iquique,
- Complejo Asistencial Dr. Victor Ríos Ruiz — Los Ángeles,
- Hospital Base San Jose de Osorno — Osorno,
- Hospital de Quilpué — Quilpué,
- Hospital Franco Ravera Zunino — Rancagua,
- Clínica Las Condes — Santiago,
- Clínica San Carlos de Apoquindo — Santiago,
- Clínica Santa Maria — Santiago,
- Clínica Universidad de los Andes — Santiago,
- Complejo Asistencial Dr. Sótero del Rio — Santiago,
- Hospital Barros Luco — Santiago,
- Hospital Clínico UC Christus — Santiago,
- Hospital Clínico Universidad de Chile — Santiago,
- Hospital Del Salvador Providencia — Santiago,
- Hospital Dra. Eloisa Diaz — Santiago,
📞 Contact the Study Coordinator
Phone: +56223543292
Email: abruhn@uc.cl
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Acute Respiratory Distress Syndrome
- Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway — Calgary, Alberta
- Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS) — Boston, Massachusetts
- ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND) — Birmingham, Alabama
- Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome — Tucson, Arizona
- Macrophage Programing in Acute Lung Injury: MiniBAL — Denver, Colorado
- Vascular ARDS Recruitment After Inhaled Nitric Oxide — Boston, Massachusetts
Explore by condition: All Acute Respiratory Distress Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.