A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain. (NCT06917404)
A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate the Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee OA pain. Study details include: * The study duration will be up to 64 weeks. * The treatment duration will be 6 weeks. * The visit frequency will be twice weekly during treatment. * The visit/contact frequency will be every 4-6 weeks during the 52-week Follow-up period. * Approximately 466 participants will be enrolled into this study.
Who can join: Review the eligibility criteria below.
Location: Onyx Clinical Research-Peoria — Peoria, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (56 Sites)
Showing the first 25 of 56 sites.
- Onyx Clinical Research-Peoria — Peoria, Arizona
- Del Sol Research Management, LLC — Tucson, Arizona
- Orange County Research Institute — Anaheim, California
- Core Healthcare Group — Cerritos, California
- Triwest Research Center — Chula Vista, California
- Seaside Medical Group — Oceanside, California
- Paragon RX Clinical — Santa Ana, California
- Encompass Clinical Research — Spring Valley, California
- Focus Clinical Research — West Hills, California
- Clinical Research of West Florida - Clearwater — Clearwater, Florida
- GNP Research — Cooper City, Florida
- Arrow Clinical Trials — Daytona Beach, Florida
- AGA Clinical Trials — Hialeah, Florida
- Evolution Clinical Trials — Miami, Florida
- Well Pharma Medical Research — Miami, Florida
- K2 Medical Research — Orlando, Florida
- Progressive Medical Research — Port Orange, Florida
- Phoenix Clinical Research — Tamarac, Florida
- Conquest Research — Winter Park, Florida
- Chicago Clinical Research, Inc — Chicago, Illinois
- Northwestern University — Chicago, Illinois
- Sinai Hospital of Baltimore — Baltimore, Maryland
- Profound Research — Farmington Hills, Michigan
- Insight Research Institute — Flint, Michigan
- Rochester Medical Group — Rochester Hills, Michigan
📞 Contact the Study Coordinator
Phone: (312) 771-9615
Email: info@paradigmbiopharma.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Osteoarthritis, Knee
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- Genicular Radiofrequency Ablation Following Total Knee Arthroplasty — Calgary, Alberta
- Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis — Sacramento, California
- Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain — Tempe, Arizona
- Prospective Randomized Study of Cementless vs Cemented UKA — New Albany, Ohio
- Clinical Outcomes of Joint Arthroplasty — St. Helena, California
Explore by condition: All Osteoarthritis, Knee clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.