AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980) (NCT07158905)
A Phase I, Randomized, Double-Blind Study to Evaluate the Safety and Tolerability of AV-1980R in Participants With Preclinical Alzheimer's Disease
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 1, multicenter, randomized, double-blind, placebo-controlled, multiple-dose-escalation study evaluating the safety, tolerability, and immunogenicity of AV-1980R, an investigational vaccine targeting pathological tau, in participants with preclinical Alzheimer's disease. Up to 48 cognitively unimpaired adults aged 65 to 80 years with biomarker evidence of preclinical Alzheimer's disease will be enrolled into three ascending-dose cohorts.
Who can join: Review the eligibility criteria below.
Location: Comprehensive Center for Brain Health — Boca Raton, Florida
Age range: 65 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (6 Sites)
- Comprehensive Center for Brain Health — Boca Raton, Florida
- Palm Springs Community Health Center — Miami Lakes, Florida
- Alzheimer's Research and Treatment Center (Stuart) — Stuart, Florida
- University of South Florida — Tampa, Florida
- Alzheimer's Research and Treatment Center (Wellington) — Wellington, Florida
- Alzheimer's Research and Treatment Center (Columbus) — Columbus, Georgia
📞 Contact the Study Coordinator
Phone: (714) 596-3981
Email: rkniazev@immed.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.