A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration (NCT07215234)
A Phase 1/2, Study to Evaluate the Safety, Tolerability, and Efficacy of One-time Intravitreal Dose of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
🩺 Plain-English Summary (8th-Grade Level)
This is a sequential Phase 1/2, two-part, multicenter study on safety, tolerability, and efficacy of one-time intravitreal SAR446597 for the treatment of participants with Geographic Atrophy (GA) secondary to Age-related Macular Degeneration (AMD). The core phase duration will be approximately 2 years for each participant. An Extended Follow-Up (EFU) phase of 3 years follows the core phase. The treatment is a one-time intravitreal injection of SAR446597 (or sham as applicable in Part II).
Who can join: Review the eligibility criteria below.
Location: Associated Retina Consultants - Peoria- Site Number : 8400011 — Peoria, Arizona
Age range: 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (18 Sites)
- Associated Retina Consultants - Peoria- Site Number : 8400011 — Peoria, Arizona
- Retina Macula Institute of Arizona- Site Number : 8400028 — Scottsdale, Arizona
- Vitreo Retinal Associates - Gainesville- Site Number : 8400004 — Gainesville, Florida
- Retina Vitreous Associates of Florida - St. Petersburg- Site Number : 8400002 — St. Petersburg, Florida
- University Retina - Lemont- Site Number : 8400005 — Lemont, Illinois
- The Retina Group of Washington - Chevy Chase- Site Number : 8400009 — Chevy Chase, Maryland
- Cumberland Valley Retina Consultants - Hagerstown- Site Number : 8400003 — Hagerstown, Maryland
- Oregon Retina- Site Number : 8400017 — Eugene, Oregon
- Mid Atlantic Retina - Bethlehem- Site Number : 8400031 — Bethlehem, Pennsylvania
- Retina Consultants of Austin- Site Number : 8400015 — Austin, Texas
- Austin Clinical Research - Austin - Anderson Mill Road- Site Number : 8400007 — Austin, Texas
- Retina Consultants of Texas - Bellaire- Site Number : 8400019 — Bellaire, Texas
- Retina Foundation of the Southwest- Site Number : 8400001 — Dallas, Texas
- Texas Retina Associates - Dallas- Site Number : 8400006 — Dallas, Texas
- Retinal Consultants of Texas - San Antonio- Site Number : 8400012 — San Antonio, Texas
- Investigational Site Number : 0360003 — Sydney, New South Wales
- Investigational Site Number : 0360002 — Adelaide, South Australia
- Investigational Site Number : 0360001 — East Melbourne, Victoria
📞 Contact the Study Coordinator
Phone: (800) 633-1610
Email: contact-us@sanofi.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Geographic Atrophy
- A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA) — Scottsdale, Arizona
- A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration — Bakersfield, California
- Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy — Phoenix, Arizona
- A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy — Gilbert, Arizona
- Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy — Phoenix, Arizona
- A Study in Adults With Geographic Atrophy — Bakersfield, California
Explore by condition: All Geographic Atrophy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.