🏛️ Verified NIH Record • Updated 2026-07-29

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation (NCT07217067)

A Randomized, Placebo-controlled, Participant- and Investigator-blinded Study to Evaluate the Efficacy in Reducing Atrial Fibrillation Burden (AFB) as Well as the Safety, Tolerability, and Pharmacokinetics of Oral PKN605 in Participants With Atrial Fibrillation

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals

🩺 Plain-English Summary (8th-Grade Level)

A randomized, placebo-controlled, participant-and investigator-blinded study to evaluate the efficacy in reducing atrial fibrillation burden as well as the safety, tolerability and pharmacokinetics of PKN605 in participants with atrial fibrillation

Who can join: Review the eligibility criteria below.

Location: Cardiology Associates of North MS — Tupelo, Mississippi

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (40 Sites)

Showing the first 25 of 40 sites.

  • Cardiology Associates of North MS — Tupelo, Mississippi
  • Cooper University Hospital — Camden, New Jersey
  • Weill Cornell Medical Center — New York, New York
  • Duke Univ Medical Center — Durham, North Carolina
  • Intermountain Medical Center — Murray, Utah
  • Swedish Heart and Vascular Clinic — Seattle, Washington
  • Novartis Investigative Site — Calgary, Alberta
  • Novartis Investigative Site — Vancouver, British Columbia
  • Novartis Investigative Site — Halifax, Nova Scotia
  • Novartis Investigative Site — Hamilton, Ontario
  • Novartis Investigative Site — London, Ontario
  • Novartis Investigative Site — Newmarket, Ontario
  • Novartis Investigative Site — Toronto, Ontario
  • Novartis Investigative Site — Toronto, Ontario
  • Novartis Investigative Site — Montreal, Quebec
  • Novartis Investigative Site — Montreal, Quebec
  • Novartis Investigative Site — Montreal, Quebec
  • Novartis Investigative Site — Québec, Quebec
  • Novartis Investigative Site — Sherbrooke, Quebec
  • Novartis Investigative Site — Beijing, Beijing Municipality
  • Novartis Investigative Site — Beijing,
  • Novartis Investigative Site — Xi'an,
  • Novartis Investigative Site — Bad Homburg,
  • Novartis Investigative Site — Berlin,
  • Novartis Investigative Site — Berlin,

📞 Contact the Study Coordinator

Phone: (888) 669-6682

Email: novartis.email@novartis.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗