A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation (NCT07625215)
A Placebo-controlled, Parallel-group, Double Blind, Randomized, Multi-cohort Phase 2 Study to Investigate Efficacy, Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BAY 3670549 in Adult Participants With Atrial Fibrillation.
🩺 Plain-English Summary (8th-Grade Level)
The main goal of this study is to find out how well BAY 3670549 works, how safe it is, how well people can tolerate it, and how the body handles the medicine. The study will compare BAY 3670549 to a placebo (a dummy treatment with no active medicine) in people with AF who need a treatment called electrical cardioversion. Electrical cardioversion is a procedure that helps the heart return to a normal rhythm. In this study, each participant will get a single intravenous (IV) infusion of either BAY 3670549 or a placebo. Participants will then be observed to see whether the heart rhythm returns to a normal rhythm. If it does not, electrical cardioversion can still be performed as planned. The study will look at how many participants return from AF to a normal rhythm, without needing electrical cardioversion and how long it takes. It will also show how many participants experience medical problems after treatment and how BAY 3670549 move into, through and out of the participants' body. The total duration of the study for an individual participant may be up two months. The findings from this study may contribute to the development of a new treatment option for people with AF.
Who can join: Review the eligibility criteria below.
Location: UCSF Advanced Heart Failure Comprehensive Care Center — San Francisco, California
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- UCSF Advanced Heart Failure Comprehensive Care Center — San Francisco, California
- UCHealth University of Colorado Hospital - Cardiology — Aurora, Colorado
- Massachusetts General Hospital - Cardiology — Boston, Massachusetts
- Henry Ford Hospital - Cardiology — Detroit, Michigan
- Duke University Hospital - Cardiology — Durham, North Carolina
- UZ Leuven Gasthuisberg - Cardiology diseases department — Leuven, Flemish Brabant
- Jessa Ziekenhuis | Hartcentrum Hasselt — Hasselt, Limburg
- AZ Delta | Clinical Trial Center - Cardiology — Roeselare, West Flanders
- University Multiprofile Hospital For Active Treatment Sveti Georgi' - EAD Department of Intensive Cardiology" — Plovdiv, Plovdiv Province
- Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department — Sofia, Sofia City Province
- University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic — Sofia, Sofia City Province
- Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Base 1 - Cardiology Department — Veliko Tarnovo, Veliko Tarnovo Province
- Medizinische Hochschule Hannover|Kardiologie und Angiologie — Hanover, Lower Saxony
- Herz-und Diabeteszentrum NRW|Elektrophysiologie/Rhythmologie — Bad Oeynhausen, North Rhine-Westphalia
- Klinikum Altenburger Land GmbH-Klinik für Kardiologie, Pneumologie und Internistische Intensivmedizin — Altenburg, Thuringia
- Tolna Vármegyei Balassa János Kórház - I. Belgyógyászati Osztály: Kardiológia, Nefrológia — Szekszárd, Tolna County
- Semmelweis Egyetem, Varosmajori Sziv- és Ergyogyaszati Klinika — Budapest,
- Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC — Acquaviva delle Fonti,
- Centro Cardiologico Monzino S.p.A. - UO Scompenso e Cardiologia Clinica — Milan,
- Azienda Ospedaliero-Universitaria Policlinico Umberto I - Malattie Cardiovascolari — Roma,
- Azienda Ospedaliero Universitaria Delle Marche - Clinica di Cardiologia e Aritmologia — Torrette,
- Maastricht UMC — Maastricht, Limburg
- Universitair Medisch Centrum Groningen — Groningen,
- American Heart of Poland S.A. - PAKS Centrum Kardiologii i Kardiochirurgii w Bielsku-Białej - Oddział Kardiologii — Bielsko-Biala,
- American Heart of Poland S.A. - MCSN, PAKS w Chrzanowie - Oddział Intensywnej Opieki Kardiologicznej — Chrzanów,
📞 Contact the Study Coordinator
Phone: (888) 842-2937
Email: clinical-trials-contact@bayer.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
- CHAMPION-AF Clinical Trial — Birmingham, Alabama
- Reversal of Atrial Substrate to Prevent Atrial — Calgary, Alberta
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
- REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry — Chandler, Arizona
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) — Cleveland, Ohio
- Liraglutide Effect in Atrial Fibrillation — Miami, Florida
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.