Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (NCT03909334)
An Open-Label Randomized Phase II Study of Combining Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor (TKI)-naïve Epidermal Growth Factor Receptor (EGFR)-Mutant Locally Advanced or Metastatic NSCLC
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of the study is to evaluate the efficacy of osimertinib plus ramucirumab versus osimertinib alone using progression free survival (PFS). Events associated with PFS include: disease progression per RECIST 1.1 and death due to any cause. A total of 150 patients will be enrolled and randomized in a 2:1 fashion (osimertinib plus ramucirumab vs. osimertinib) to the two treatment arms according to the following stratification factors: types of epidermal growth factor receptor (EGFR) mutations and presence of brain metastasis.
Who can join: Review the eligibility criteria below.
Location: Georgetown University — Washington D.C., District of Columbia
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- Georgetown University — Washington D.C., District of Columbia
- Moffitt Cancer Center — Tampa, Florida
- Northwestern University Feinberg School of Medicine — Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois
- Indiana Univesity Melvin and Bren Simon Cancer Center — Indianapolis, Indiana
- Summit Medical Group, PA — Berkeley Heights, New Jersey
- New York University Cancer Center — New York, New York
- Columbia University Irving Medical Center — New York, New York
- Providence Portland Medical Center — Portland, Oregon
- MD Anderson Cancer Center — Houston, Texas
- University of Virginia Health System — Charlottesville, Virginia
- Fred Hutchinson Cancer Research Center — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.