A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer (NCT04036682)
A Phase 1/2, Open-Label, Multi-Center Trial to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CLN-081 in Patients With Locally-Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations Who Have Previously Received Platinum-Based Systemic Chemotherapy
๐ฉบ Plain-English Summary (8th-Grade Level)
CLN-081-001 is a Phase 1/2, open label, multi-center study of CLN-081 in patients with non-small cell lung cancer (NSCLC) harboring EGFR (epidermal growth factor receptor) exon 20 insertion mutations, to characterize the safety, determine the recommended Phase 2 dose (RP2D), and evaluate efficacy.
Who can join: Review the eligibility criteria below.
Location: Pacific Cancer Medical Center, Inc โ Anaheim, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (64 Sites)
Showing the first 25 of 64 sites.
- Pacific Cancer Medical Center, Inc โ Anaheim, California
- City of Hope Comprehensive Cancer Center โ Duarte, California
- City of Hope at Irvine Lennar โ Irvine, California
- Pacific Shores Medical Group โ Long Beach, California
- AdventHealth โ Orlando, Florida
- Massachusetts General Hospital โ Boston, Massachusetts
- University of Michigan Health System - University Hospital โ Ann Arbor, Michigan
- Summit Medical Group PA โ Florham Park, New Jersey
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island โ Mineola, New York
- New York University Langone Health โ New York, New York
- Columbia University Irving Medical Center โ New York, New York
- Memorial Sloan Kettering Cancer Center โ New York, New York
- Gabrail Cancer Center Research โ Canton, Ohio
- Providence Cancer Center โ Portland, Oregon
- Providence Oncology & Hematology Care Clinic-Westside โ Portland, Oregon
- UPMC Hillman Cancer Center โ Pittsburgh, Pennsylvania
- Medical University of South Carolina โ Charleston, South Carolina
- Virginia Cancer Specialists โ Fairfax, Virginia
- Hong Kong University - Queen Mary Hospital โ Hong Kong,
- Azienda Ospedaliero Universitaria Careggi โ Careggi,
- Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I โ Marche,
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS โ Meldola,
- IRCCS-Istituto Europeo di Oncologia โ Milan,
- Azienda Ospedaliero Universitaria Modena โ Modena,
- San Gerardo Hospital โ Monza,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Non Small Cell Lung Cancer clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.