A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas (NCT04104776)
A Phase 1/2 Study of DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of DZR123 (Tulmimetostat, CPI-0209), both as monotherapy and in combination with enzalutamide, in patients with advanced solid tumors and lymphomas.
Who can join: Review the eligibility criteria below.
Location: H. Lee Moffitt Cancer Center & Research Institute โ Tampa, Florida
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (80 Sites)
Showing the first 25 of 80 sites.
- H. Lee Moffitt Cancer Center & Research Institute โ Tampa, Florida
- Winship Cancer Institute of Emory University โ Atlanta, Georgia
- University of Chicago Medical Center โ Chicago, Illinois
- Loyola University Medical Center โ Maywood, Illinois
- University of Maryland Greenebaum Cancer Center โ Baltimore, Maryland
- Massachusetts General Hospital โ Boston, Massachusetts
- Dana Farber Cancer Institute โ Boston, Massachusetts
- University of Michigan Hospitals โ Ann Arbor, Michigan
- South Texas Accelerated Research Therapeutics (START) - Midwest Location โ Grand Rapids, Michigan
- Hackensack University Medical Center โ Hackensack, New Jersey
- Roswell Park Cancer Institute โ Buffalo, New York
- Laura and Isaac Perlmutter Cancer Center at NYU Langone โ New York, New York
- Memorial Sloan Kettering Cancer Center - NYC โ New York, New York
- Weill Medical College of Cornell University โ New York, New York
- University of Rochester Medical Center, James P. Wilmot Cancer Center โ Rochester, New York
- Montefiore Medical Center, Montefiore Medical Center Laboratories โ The Bronx, New York
- University of Cincinnati Medical Center โ Cincinnati, Ohio
- Abramson Cancer Center of the University of Pennsylvania โ Philadelphia, Pennsylvania
- South Texas Accelerated Research Therapeutics โ San Antonio, Texas
- University of Virginia Health System โ Charlottesville, Virginia
- Swedish Cancer Institute โ Seattle, Washington
- Fred Hutchinson Cancer Center โ Seattle, Washington
- CHU Bordeaux Hopital Saint Andre โ Bordeaux,
- CLCC Institut Bergonie โ Bordeaux,
- Centre Oscar Lambret โ Lille,
๐ Contact the Study Coordinator
Phone: (888) 669-6682
Email: novartis.email@novartis.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Solid Tumor
- Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression โ Iowa City, Iowa
- A Phase 1/2 Study of OBI-992 in Subjects With Advanced Solid Tumors โ Glendale, California
- QTX3046 in Patients With KRAS G12D Mutations โ Grand Rapids, Michigan
- A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors โ Houston, Texas
- First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer โ Fullerton, California
- A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors โ San Antonio, Texas
Explore by condition: All Advanced Solid Tumor clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.