๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-18

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas (NCT04104776)

A Phase 1/2 Study of DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

๐ŸŸข Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of DZR123 (Tulmimetostat, CPI-0209), both as monotherapy and in combination with enzalutamide, in patients with advanced solid tumors and lymphomas.

Who can join: Review the eligibility criteria below.

Location: H. Lee Moffitt Cancer Center & Research Institute โ€” Tampa, Florida

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (80 Sites)

Showing the first 25 of 80 sites.

  • H. Lee Moffitt Cancer Center & Research Institute โ€” Tampa, Florida
  • Winship Cancer Institute of Emory University โ€” Atlanta, Georgia
  • University of Chicago Medical Center โ€” Chicago, Illinois
  • Loyola University Medical Center โ€” Maywood, Illinois
  • University of Maryland Greenebaum Cancer Center โ€” Baltimore, Maryland
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • Dana Farber Cancer Institute โ€” Boston, Massachusetts
  • University of Michigan Hospitals โ€” Ann Arbor, Michigan
  • South Texas Accelerated Research Therapeutics (START) - Midwest Location โ€” Grand Rapids, Michigan
  • Hackensack University Medical Center โ€” Hackensack, New Jersey
  • Roswell Park Cancer Institute โ€” Buffalo, New York
  • Laura and Isaac Perlmutter Cancer Center at NYU Langone โ€” New York, New York
  • Memorial Sloan Kettering Cancer Center - NYC โ€” New York, New York
  • Weill Medical College of Cornell University โ€” New York, New York
  • University of Rochester Medical Center, James P. Wilmot Cancer Center โ€” Rochester, New York
  • Montefiore Medical Center, Montefiore Medical Center Laboratories โ€” The Bronx, New York
  • University of Cincinnati Medical Center โ€” Cincinnati, Ohio
  • Abramson Cancer Center of the University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • South Texas Accelerated Research Therapeutics โ€” San Antonio, Texas
  • University of Virginia Health System โ€” Charlottesville, Virginia
  • Swedish Cancer Institute โ€” Seattle, Washington
  • Fred Hutchinson Cancer Center โ€” Seattle, Washington
  • CHU Bordeaux Hopital Saint Andre โ€” Bordeaux,
  • CLCC Institut Bergonie โ€” Bordeaux,
  • Centre Oscar Lambret โ€” Lille,

๐Ÿ“ž Contact the Study Coordinator

Phone: (888) 669-6682

Email: novartis.email@novartis.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—