A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations (NCT05163028)
A Phase 1, Open-Label, Dose Escalation of HBI-2376 in Patients With Advanced Malignant Solid Tumors Harboring KRAS or EGFR Mutations
🩺 Plain-English Summary (8th-Grade Level)
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.
Who can join: Review the eligibility criteria below.
Location: City of Hope — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- City of Hope — Duarte, California
- California Cancer Associates for Research and Excellence, Inc. (cCare) — Encinitas, California
- Providence Medical Foundation — Fullerton, California
- California Cancer Associates for Research and Excellence, Inc. (cCare) — San Marcos, California
- Sarcoma Oncology — Santa Monica, California
- UCLA Hematology/Oncology — Santa Monica, California
- Orlando Health, Inc. — Orlando, Florida
- BRCR Medical Center — Plantation, Florida
- Gabrail Cancer Center — Canton, Ohio
- Texas Oncology - Tyler — Tyler, Texas
- Virginia Cancer Specialists — Fairfax, Virginia
- Pan American Center for Oncology Trials (PanOncology Trials) — Rio Piedras, Puerto Rico
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.