๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-03

Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) (NCT05552755)

A Phase 1b-2, Multicenter, Trial to Evaluate the Efficacy, Safety, Pharmacokintetics, and Pharmacodynamics of REC-4881 in Patients With Familial Adenomatous Polyposis (FAP)

๐ŸŸข Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Recursion Pharmaceuticals Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a multicenter, two-part trial in participants with FAP.

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic - Scottsdale โ€” Scottsdale, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (17 Sites)

  • Mayo Clinic - Scottsdale โ€” Scottsdale, Arizona
  • Del Sol Research Management โ€” Tucson, Arizona
  • Medical Associates Research Group โ€” San Diego, California
  • GI Pros โ€” Naples, Florida
  • Digestive and Liver Center of Florida โ€” Orlando, Florida
  • Gastroenterology Health Partners, PLLC โ€” New Albany, Indiana
  • Tandem Clinical Research โ€” Marrero, Louisiana
  • Corewell Health (Spectrum Health Hospitals Colorectal Cancer Multis) โ€” Grand Rapids, Michigan
  • Mayo Clinic - Rochester โ€” Rochester, Minnesota
  • Washington University School of Medicine โ€” St Louis, Missouri
  • University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • Gastro One-8110 Walnut Rs โ€” Cordova, Tennessee
  • Vanderbilt Digestive Center โ€” Nashville, Tennessee
  • Genetic Cancer Prevention Clinic - UT Southwestern โ€” Dallas, Texas
  • MD Anderson Cancer Center โ€” Houston, Texas
  • Huntsman Cancer Institute and University of Utah โ€” Salt Lake City, Utah
  • Benaroya Research Institute at Virginia Mason โ€” Seattle, Washington

๐Ÿ“ž Contact the Study Coordinator

Phone: (385) 374-1724

Email: clinicaltrials@recursion.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—