๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-18

XTX301 in Patients With Advanced Solid Tumors (NCT05684965)

A First-in-Human, Multicenter, Phase 1/2, Open-Label Study of XTX301 in Patients With Advanced Solid Tumors

๐ŸŸข Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Xilio Development, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a first-in-human, multicenter, Phase 1/2, open-label study designed to evaluate the safety and tolerability of XTX301 as monotherapy in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: University of California, Davis Comprehensive Cancer Center โ€” Sacramento, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (12 Sites)

  • University of California, Davis Comprehensive Cancer Center โ€” Sacramento, California
  • Yale Cancer Center โ€” New Haven, Connecticut
  • HealthPartners Frauenshuh Cancer center โ€” Saint Louis Park, Minnesota
  • Washington University School of Medicine โ€” St Louis, Missouri
  • Hackensack University Medical Center โ€” Hackensack, New Jersey
  • The Gabrail Pharmacology Phase 1 Research Center โ€” Canton, Ohio
  • University Hospital Cleveland Medical Center โ€” Cleveland, Ohio
  • The Ohio State University Wexner Medical Center โ€” Columbus, Ohio
  • University of Pittsburgh Medical Center-Hillman Cancer Center โ€” Pittsburgh, Pennsylvania
  • Tranquil Clinical Research โ€” Webster, Texas
  • Medical College of Wisconsin โ€” Milwaukee, Wisconsin
  • Sheboygan Cancer & Blood Specialists โ€” Sheboygan, Wisconsin

๐Ÿ“ž Contact the Study Coordinator

Phone: (857) 524-2466

Email: medicalaffairs@xiliotx.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—