Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors (NCT05887492)
A Phase 1/2, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of TNG260 as Single Agent and in Combination With an Anti-PD-1 Antibody In Patients With STK11 Mutated Advanced Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
The goal of this interventional clinical trial is to learn about TNG260, a CoREST inhibitor, in combination with pembrolizumab in patients with advanced solid tumors with a known STK11 mutation. The main question\[s\] it aims to answer are: * the recommended dose for Phase 2 * to evaluate the safety and tolerability of the combination therapy * to determine the pharmacokinetics of TNG260 * to evaluate the initial antineoplastic activity Participants will receive study treatment until they experience an undesirable side effect, their disease progresses or until they withdraw consent.
Who can join: Review the eligibility criteria below.
Location: UCLA Hematology/Oncology — Santa Monica, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- UCLA Hematology/Oncology — Santa Monica, California
- SCRI at HealthOne — Denver, Colorado
- Florida Cancer Specialists — Sarasota, Florida
- Dana Farber Cancer Institute — Boston, Massachusetts
- Henry Ford Health System — Detroit, Michigan
- START MidWest — Grand Rapids, Michigan
- NYU Langone Hematology Oncology Associates-Mineola — Mineola, New York
- New York University Langone Health — New York, New York
- Sarah Cannon Tennessee Oncology — Nashville, Tennessee
- US Oncology Investigational Products Center — Dallas, Texas
- The University of Texas MD Anderson Cancer Center — Houston, Texas
- NEXT Oncology Virginia — Fairfax, Virginia
- US Oncology Investigational Products Center — Norfolk, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.