🏛️ Verified NIH Record • Updated 2026-07-06

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors (NCT06233942)

Phase 1a/1b Study of BG-C9074, an Antibody Drug Conjugate Targeting B7H4, as Monotherapy and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: BeOne Medicines

🩺 Plain-English Summary (8th-Grade Level)

This is a first-in-human, dose finding and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C9074 alone and in combination with other anticancer therapies in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: Usc Norris Comprehensive Cancer Center (Nccc) — Los Angeles, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (37 Sites)

Showing the first 25 of 37 sites.

  • Usc Norris Comprehensive Cancer Center (Nccc) — Los Angeles, California
  • University of Colorado Cancer Center — Aurora, Colorado
  • Florida Cancer Specialist Research Institute Lake Nona — Orlando, Florida
  • Sidney Kimmel Comprehensive Cancer At Johns Hopkins — Baltimore, Maryland
  • James Cancer Hospital and Solove Research Institute — Columbus, Ohio
  • Blacktown Cancer and Haematology Centre — Blacktown, New South Wales
  • Macquarie University — North Ryde, New South Wales
  • Cancer Care Wollongong — Wollongong, New South Wales
  • Princess Alexandra Hospital — Woolloongabba, Queensland
  • Monash Health — Clayton, Victoria
  • Cabrini Hospital Malvern — Malvern, Victoria
  • Peter Maccallum Cancer Centre — Melbourne, Victoria
  • Linear Clinical Research — Nedlands, Western Australia
  • Hospital Sirio Libanes Brasilia — Brasília,
  • Liga Norte Riograndene Contra O Cancer — Natal,
  • Hospital Sao Lucas Da Pucrs — Porto Alegre,
  • Instituto Nacional de Cancer Hospital Do Cancer Ii — Rio de Janerio,
  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José do Rio Preto,
  • Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira — São Paulo,
  • Clinica de Pesquisa E Centro de Estudos Em Oncologia Ginecologica E Mamaria — São Paulo,
  • Cancer Hospital Chinese Academy of Medical Sciences — Beijing, Beijing Municipality
  • Fujian Cancer Hospital — Fuzhou, Fujian
  • Sun Yat Sen University Cancer Center — Guangzhou, Guangdong
  • Harbin Medical University Cancer Hospital — Harbin, Heilongjiang
  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei

📞 Contact the Study Coordinator

Phone: (877) 828-5568

Email: clinicaltrials@beonemed.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗