๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-17

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors (NCT06244485)

A Phase 1b, Multicenter, Open-Label Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Daiichi Sankyo

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study will evaluate the safety, tolerability, and efficacy of valemetostat tosylate in combination with DXd ADC in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: City of Hope At Orange County Lennar Foundation Cancer Center โ€” Irvine, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (35 Sites)

Showing the first 25 of 35 sites.

  • City of Hope At Orange County Lennar Foundation Cancer Center โ€” Irvine, California
  • Sharp Memorial Hospital โ€” San Diego, California
  • Brcr Medical Center, Inc Dba Boca Raton Clinical Research โ€” Plantation, Florida
  • University of Hawaii At Manoa โ€” Honolulu, Hawaii
  • University of Chicago Medical Center โ€” Chicago, Illinois
  • Dana-Farber Cancer Institute โ€” Boston, Massachusetts
  • Memorial Sloan-Kettering Cancer Center (Mskcc) - New York โ€” New York, New York
  • Clinical Research Alliance โ€” Westbury, New York
  • Unc Hospitals โ€” Chapel Hill, North Carolina
  • The Cleveland Clinic Foundation โ€” Cleveland, Ohio
  • Providence Portland Medical Center โ€” Portland, Oregon
  • Mary Crowley Cancer Research Centers โ€” Dallas, Texas
  • Ut Southwestern Medical Center โ€” Dallas, Texas
  • University of Texas M. D. Anderson Cancer Center โ€” Houston, Texas
  • Next Virginia โ€” Fairfax, Virginia
  • Fred Hutchinson Cancer Center โ€” Seattle, Washington
  • Medical College of Wisconsin โ€” Milwaukee, Wisconsin
  • Peking University Third Hospital โ€” Beijing,
  • Sun Yat-Sen University, Cancer Center โ€” Guangzhou,
  • SunYat-Sen University Cancer Center โ€” Guangzhou,
  • Harbin Medical Univeristy Cancer Hospital โ€” Heilongjiang,
  • Hunan Cancer Hospital โ€” Hunan,
  • Jilin Cancer Hospital โ€” Jilin City,
  • Jinana Center Hosptial โ€” Shandong,
  • IRCCS Istituto Scientifico Romagnolo Per โ€” Cesena,

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—