Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (NCT07037459)
A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)
🩺 Plain-English Summary (8th-Grade Level)
This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Saint Vincent's Birmingham — Birmingham, Alabama
Age range: 18 Years to 99 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (628 Sites)
Showing the first 25 of 628 sites.
- University of Alabama Saint Vincent's Birmingham — Birmingham, Alabama
- SEC Clinical Research — Dothan, Alabama
- Eastern Shore Research Institute — Fairhope, Alabama
- Heart Center Research LLC — Huntsville, Alabama
- HonorHealth — Phoenix, Arizona
- Medical Advancement Centers of Arizona — Phoenix, Arizona
- Pima Heart and Vascular Clinical Research — Tucson, Arizona
- Yuma Clinical Trials — Yuma, Arizona
- Arkansas Cardiology — Little Rock, Arkansas
- National Heart Institute — Beverly Hills, California
- Valley Clinical Trials, LLC dba Flourish Research — Covina, California
- National Institute of Clinical Research — Huntington Beach, California
- 310 Clinical Research — Inglewood, California
- Radin Cardiovascular Medical Group — Newport Beach, California
- Valley Clinical Trials — Northridge, California
- University of California Irvine — Orange, California
- Empire Clinical Research — Pomona, California
- San Diego Cardiac Center — San Diego, California
- NorthBay Clinical Research LLC — Santa Rosa, California
- Manshadi Heart Institute — Stockton, California
- Cardiology Associates of Fairfield County PC — Stamford, Connecticut
- Orlando Heart and Vascular Institute — Altamonte Springs, Florida
- D and H Tamarac Research Center — Aventura, Florida
- Excel Medical Clinical Trials — Boca Raton, Florida
- Cardiovascular and Vein Center of Florida — Bradenton, Florida
📞 Contact the Study Coordinator
Phone: (866) 572-6436
Email: medinfo@amgen.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction — Naples, Florida
- IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency — Durham, North Carolina
- Matching Perfusion and Metabolic Activity in HFpEF — Philadelphia, Pennsylvania
- Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction — Kelowna, British Columbia
Explore by condition: All Heart Failure With Preserved Ejection Fraction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.