100 Recruiting Studies at City Of Hope
Active clinical trials at this research center, sourced directly from the NIH registry.
📍 Duarte, California
All research centersRecruiting Studies at City Of Hope
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Acute Leukemia
View Study & Checklist ➔Venetoclax + Azacitidine vs. Induction Chemotherapy in AML
Acute Myeloid Leukemia
View Study & Checklist ➔Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Acute Myeloid Leukemia
View Study & Checklist ➔Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Acute Myeloid Leukemia
View Study & Checklist ➔Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS
Acute Myeloid Leukemia
View Study & Checklist ➔A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML
Acute Myeloid Leukemia
View Study & Checklist ➔A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias
Acute Myeloid Leukemias
View Study & Checklist ➔Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
Advanced/Metastatic Clear Cell Renal Cell Carcinoma
View Study & Checklist ➔A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis
Amyloidosis
View Study & Checklist ➔Phase 1 Study of Autologous CD30.CAR-T in Relapsed or Refractory CD30 Positive Non-Hodgkin Lymphoma
Anaplastic Large Cell Lymphoma
View Study & Checklist ➔Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
Bladder Cancer
View Study & Checklist ➔Positron Emission Tomography in Women With Advanced HER2-Positive Breast Cancer
Breast Cancer
View Study & Checklist ➔Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life
Breast Cancer
View Study & Checklist ➔Robotic vs. Open NSM for Early Stage Breast Cancer
Breast Cancer Female
View Study & Checklist ➔Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History
Breast Cancer Survivors
View Study & Checklist ➔A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab
Cancer
View Study & Checklist ➔Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors
Cancer
View Study & Checklist ➔A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung
View Study & Checklist ➔Enzalutamide With or Without Radium Ra 223 Dichloride in Patients With Metastatic, Castration-Resistant Prostate Cancer
Castration-Resistant Prostate Carcinoma
View Study & Checklist ➔Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies
CLL/SLL
View Study & Checklist ➔A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors
Colorectal Cancer
View Study & Checklist ➔Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer
Colorectal Cancer
View Study & Checklist ➔A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer
Endometroid Endometrial Cancer
View Study & Checklist ➔Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers
Gastric Cancer
View Study & Checklist ➔INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)
Glioblastoma
View Study & Checklist ➔Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma
Hematological Malignancies
View Study & Checklist ➔Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
View Study & Checklist ➔A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Lymphoma, Non-Hodgkin
View Study & Checklist ➔A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma
Lymphoma, Non-Hodgkin
View Study & Checklist ➔P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔Phase II Study of IRD (Ixazomib, Lenalidomide, Dexamethasone) Post Autologous Stem Cell Transplantation Followed by Maintenance Ixazomib or Lenalidomide for Multiple Myeloma
Multiple Myeloma
View Study & Checklist ➔Pembrolizumab in Muscle-invasive Bladder Cancer
Muscle Invasive Bladder Carcinoma
View Study & Checklist ➔A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis
Myelofibrosis
View Study & Checklist ➔A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
Nasopharyngeal Carcinoma
View Study & Checklist ➔Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation
Newly Diagnosed Acute Myeloid Leukemia (AML)
View Study & Checklist ➔Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)
Non Hodgkin Lymphoma
View Study & Checklist ➔A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
Non Small Cell Lung Cancer
View Study & Checklist ➔U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer (NSCLC)
View Study & Checklist ➔Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Ovarian Cancer
View Study & Checklist ➔The Impact of Androgen Ablation Therapy on Cognitive Functioning and Functional Status in Men With Prostate Cancer Age 65 and Older
Prostate Cancer
View Study & Checklist ➔Pembrolizumab and Lenvatinib in Advanced/Metastatic Neuroendocrine Prostate Cancer
Prostate Cancer Metastatic
View Study & Checklist ➔MMRC Horizon One: RRMM (MMRC-099)
Relapse Multiple Myeloma
View Study & Checklist ➔A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
Rett Syndrome
View Study & Checklist ➔A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors
Solid Tumor
View Study & Checklist ➔A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
Solid Tumor, Adult
View Study & Checklist ➔Multicohort Phase II Trial of sEphB4-HSA+Pembrolizumab in Solid Tumors
Stage IV Bladder Urothelial Carcinoma
View Study & Checklist ➔Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer
Stage IV Prostate Adenocarcinoma AJCC v7
View Study & Checklist ➔Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Synovial Sarcoma
View Study & Checklist ➔Study of Vimseltinib for Tenosynovial Giant Cell Tumor
Tenosynovial Giant Cell Tumor
View Study & Checklist ➔A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients
AML (Acute Myeloid Leukemia)
View Study & Checklist ➔Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy
Atrial Fibrillation (AF)
View Study & Checklist ➔The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.
Gastric Cancer
View Study & Checklist ➔A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
Acute Leukemia
View Study & Checklist ➔SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Acute Myeloid Leukemia
View Study & Checklist ➔A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Acute Myeloid Leukemia
View Study & Checklist ➔A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma
View Study & Checklist ➔Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma
Advanced Hodgkin Lymphoma
View Study & Checklist ➔A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor
View Study & Checklist ➔This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor
View Study & Checklist ➔Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer
Advanced Urothelial Cancer
View Study & Checklist ➔A Long Term Follow-up Study of TScan TCR-T Products
AML
View Study & Checklist ➔A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation
AML
View Study & Checklist ➔Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML
AML, Adult
View Study & Checklist ➔The HOPE Biobank Resource (BMT CTN 2402 HOPE)
Aplastic Anemias
View Study & Checklist ➔Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
B-cell Acute Lymphoblastic Leukemia
View Study & Checklist ➔A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas
B-cell Non-Hodgkins Lymphoma (B-NHL)
View Study & Checklist ➔A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
Bladder Cancer
View Study & Checklist ➔Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
Bone Pain
View Study & Checklist ➔cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Brain Cancer
View Study & Checklist ➔A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Breast Cancer
View Study & Checklist ➔A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Breast Neoplasms
View Study & Checklist ➔Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
Cancer
View Study & Checklist ➔Evaluation of a Telehealth Oncofertility Care Intervention in Adolescent and Young Adult Cancer Patients
Cancer
View Study & Checklist ➔A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC
Carcinoma, Non-Small-Cell Lung
View Study & Checklist ➔Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer
Castration-resistant Prostate Cancer
View Study & Checklist ➔Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease
Chronic Graft Versus Host Disease
View Study & Checklist ➔A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Chronic Lymphocytic Leukemia (CLL)
View Study & Checklist ➔A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)
Chronic Lymphocytic Leukemia (CLL)
View Study & Checklist ➔A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
Chronic Lymphocytic Leukemia (CLL)
View Study & Checklist ➔Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
CLL/SLL
View Study & Checklist ➔A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers
Colorectal Cancer
View Study & Checklist ➔A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Diabetes Mellitus, Type 1
View Study & Checklist ➔Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant
E Coli Infections
View Study & Checklist ➔Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
Familial Adenomatous Polyposis (FAP)
View Study & Checklist ➔A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer
Gastric Adenocarcinoma
View Study & Checklist ➔Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
Gastrointestinal Neoplasm Malignant
View Study & Checklist ➔A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
Head and Neck Squamous Cell Carcinoma
View Study & Checklist ➔Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
Hematologic Malignancy
View Study & Checklist ➔GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
Hepatocellular Carcinoma
View Study & Checklist ➔A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias
High-risk Myelodysplastic Syndrome
View Study & Checklist ➔A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors
HR+ Breast Cancer
View Study & Checklist ➔A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
View Study & Checklist ➔Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer
Locally Advanced Lung Non-Small Cell Carcinoma
View Study & Checklist ➔A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer.
Locally Advanced Pancreatic Adenocarcinoma
View Study & Checklist ➔Padeliporfin VTP Treatment for Unresectable Pancreatic Adenocarcinoma
Locally Advanced Unresectable Pancreatic Adenocarcinoma
View Study & Checklist ➔The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
Lymphoid Malignancies
View Study & Checklist ➔A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies
Lymphoma, B-Cell
View Study & Checklist ➔A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Lymphoma, Non-Hodgkin
View Study & Checklist ➔Confirmatory Clinical Evaluation of Novilase® Laser Therapy for Focal Destruction of Malignant Breast Tumors
Malignant Neoplasm of Breast
View Study & Checklist ➔